Kazuma Satou[]
Chomusuke gets along very well with Kazuma, partially because the latter always dotes on Chomusuke. Chomusuke (as the Dark God of Sloth) appears to be attracted to Kazuma's lazy attitude. Chomusuke's relationship with Kazuma is so good that Megumin has been known to get jealous of their relationship. Possibly under the influence of Wolbach, Chomusuke often chooses to bath with Kazuma just as Wolbach had done in the past.
Aqua[]
Even before absorbing Wolbach and taking on a lot of her traits, Chomusuke held a grudge against the Goddess of Water. Every time Aqua tries to stroke or dote on Chomusuke, the latter scratches Aqua. After absorbing Wolbach, Chomusuke begins going out of her way to hurt Aqua, such as tearing up her clothes, which is most likely due to Wolbach's rivalry with Aqua.
Emperor Zell[]
Chomusuke doesn't get along at all with Aqua's pet chicken, Emperor Zell. For some strange reason, Chomusuke seems to be afraid of Zell, usually running away from him even though he poses no physical threat to Chomusuke. This may be because of Zell's high mana reserves.
Megumin[]
Chomusuke gets along pretty well with Megumin and accepts her as her master. This is due to Chomusuke being the Dark God of Violence and she is attracted to Megumin's violent nature.